Phenoxyalkanoic acid sweetness inhibitors
1991
Substituted phenoxyalkanoic acids are potent inhibitors of the sweetness response. The degree of inhibition of sweetness is dependent on the concentration of substituted phenoxyalkanoic acid in a sweetener-inhibitor mixture. In contrast to some other sweetness inhibitors, pre-treatment of the tongue is not necessary and the inhibitory effect is immediate and rapidly reversible. The acidic group, or its salt, is necessary, and the nature, position and degree of substitution on the phenyl moiety influences potency. The results of sensory studies designed to determine the possible mechanism of action are described, and the implications for our understanding of the mechanism whereby sweeteners induce their effects are discussed.
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