Ball milling – a new concept for predicting degradation profiles in active pharmaceutical ingredients
2021
Kaiser, Reinhard P. | Krake, Everaldo F. | Backer, Laura | Urlaub, Jonas | Baumann, W. (Wolfgang) | Handler, Norbert | Buschmann, Helmut | Beweries, Torsten | Holzgrabe, U. (Ulrike) | Bolm, Carsten
A method for forced oxidative mechanochemical degradation of active pharmaceutical ingredients (APIs) using clopidogrel hydrogensulfate as a model compound is presented. Considerable and selective formation of degradants occurs already after very short reaction times of less than 15 minutes and the nature of the products is strongly dependent on the used oxidant.
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