Ball milling – a new concept for predicting degradation profiles in active pharmaceutical ingredients
2021
Kaiser, Reinhard P. | Krake, Everaldo F. | Backer, Laura | Urlaub, Jonas | Baumann, W. (Wolfgang) | Handler, Norbert | Buschmann, Helmut | Beweries, Torsten | Holzgrabe, U. (Ulrike) | Bolm, Carsten
A method for forced oxidative mechanochemical degradation of active pharmaceutical ingredients (APIs) using clopidogrel hydrogensulfate as a model compound is presented. Considerable and selective formation of degradants occurs already after very short reaction times of less than 15 minutes and the nature of the products is strongly dependent on the used oxidant.
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书目信息
出版者
The Royal Society of Chemistry
其它主题
Mechanochemistry; Active pharmaceutical ingredients; Chemical communication
语言
英语
类型
Journal Article; Text
2024-02-28
MODS