Contributions des bactéries commensales et de l’hôte à la cholestérolémie | Contributions of commensal bacteria and host to cholesterolemia
2020
Lesnik, Philippe
Large interindividual variations in plasma cholesterol are traditionally related to genetic factors and the residual portion of their variance is attributed to environmental factors, including diet. Preclinical studies have suggested that the microbiota plays a key role in inflammatory and metabolic disorders. Alterations in gut microbiota composition in humans have also been linked to a variety of inflammatory/metabolic diseases and epidemiological studies report associations between bacterial phyla and cholesterolemia. Cholesterol metabolism and microbiology are areas of research that display very little overlapping. This association remains largely unexplored although endocrinologist and microbiologist pay much attention to respectively cholesterol-nutrition and nutrition-microbe relationships. The objectives of this review are to present the current knowledge and potential mechanisms underlying this dialogue in order to stimulate research on the prokaryotic world's contribution to the regulation of cholesterol homeostasis in the host.
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