PTPMT1: Connecting Cardiolipin Biosynthesis to Mitochondrial Function
2011
El-Kouhen, Karim | Tremblay, Michel L.
Cardiolipin, a phospholipid component of the inner mitochondrial membrane, is required for mitochondrial metabolism. In this issue, Zhang et al. (2011) highlight a critical role for PTPMT1, a mitochondrial phosphatase, in cardiolipin biogenesis and possibly in cardiolipin deficiency diseases. Their findings also unveil a yet uncharacterized pathway affecting cell growth.
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