Aminomethylation of Aryl Bromides by Nickel-Catalyzed Electrochemical Redox Neutral Cross Coupling
2021
Ma, Yueyue | Hong, Jufei | Yao, Xiantong | Liu, Chengyu | Zhang, Ling | Fu, Youtian | Sun, Maolin | Cheng, Ruihua | Li, Zhong | Ye, Jinxing
We develop an electrochemical nickel-catalyzed aminomethylation of aryl bromides under mild conditions. The convergent paired electrolysis makes full use of anode and cathode processes, free of a terminal oxidant, a sacrificial anode, a metal reductant, and a prefunctionalized radical precursor. In addition, this method exhibits wide functional group tolerance (63 examples), including some sensitive substituents and aromatic heterocycles. This redox neutral cross coupling provides a more environmentally friendly and synthetic practical protocol for forging C(sp²)–C(sp³) bonds.
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