Catalytic Enantioselective Birch–Heck Sequence for the Synthesis of Tricyclic Structures with All-Carbon Quaternary Stereocenters

Krasley, Andrew T.; Malachowski, William P.; Terz, Hannah M.; Tran Tien, Sabrina

Catalytic Enantioselective Birch–Heck Sequence for the Synthesis of Tricyclic Structures with All-Carbon Quaternary Stereocenters

2018

Krasley, Andrew T. | Malachowski, William P. | Terz, Hannah M. | Tran Tien, Sabrina

A new enantioselective desymmetrizing Mizoroki–Heck reaction is reported. The process affords high yields and enantioselectivities of tricyclic structures containing all-carbon quaternary stereocenters. The substrates for the reaction are efficiently synthesized from Birch reduction–alkylation of benzoic acid and benzoate esters.

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