Heck–Mizoroki coupling of vinyliodide and applications in the synthesis of dienes and trienes

Madden, Katrina S.; David, Sylvain; Knowles, Jonathan P.; Whiting, Andrew

Heck–Mizoroki coupling of vinyliodide and applications in the synthesis of dienes and trienes

2015

Madden, Katrina S. | David, Sylvain | Knowles, Jonathan P. | Whiting, Andrew

Vinyliodide reacts chemoselectively under Heck–Mizoroki conditions with terminal alkenes, including vinylboronate esters, to give dienes. The resulting dienylboronates undergo Suzuki–Miyaura couplings with aryl, heteroaryl and alkenyl halides to access dienes and trienes.

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