An expedient osmium(vi)/K₃Fe(CN)₆-mediated selective oxidation of benzylic, allylic and propargylic alcohols

Fernandes, Rodney A.; Bethi, Venkati

An expedient osmium(vi)/K₃Fe(CN)₆-mediated selective oxidation of benzylic, allylic and propargylic alcohols

2014

Fernandes, Rodney A. | Bethi, Venkati

A chemoselective osmium(vi) catalyzed oxidation of benzylic, allylic and propargylic alcohols using K₃Fe(CN)₆ as a secondary oxidant is described. This protocol is operationally simple and exhibits excellent chemoselectivity favouring the oxidation of benzylic alcohols over the aliphatic alcohols. A larger scale reaction was also found to be compatible.

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