Impact of wheat on the non-specific immune response of man. II. Whole wheat

Watzl, B.; Feyll, K.; Ruhl, H.; Leitzmann, C.

Impact of wheat on the non-specific immune response of man. II. Whole wheat

1990

Watzl, B. | Feyll, K. | Ruhl, H. | Leitzmann, C.

In a blind cross over study the impact of short-term whole wheat consumption and in a prospective study the impact of long-term whole wheat consumption was measured on the non-specific immune response. Volunteers (n = 16) regularly consuming whole wheat participated in the cross over study and were divided into two groups. Each group consumed whole wheat products for 10 days and white flour products for another 10 days. Another 16 volunteers participated in the prospective study, 8 that consumed whole wheat products regularly and 8 that never consumed whole wheat. The measured immune parameters were: phagocytic capacity of PMNL, specific activity of NK cells and serum lysozyme concentration. In the cross over study no differences between the groups were detected in the activity of the NK cells and the lysozyme concentration. The phagocytic capacity of PMNL during whole wheat consumption at day 2 and 10 was significantly higher (p<0.001 and 0.05) than in the control In the prospective study no statistical significant differences between the groups were detected for the phagocytic capacity of PMNL and the activity of the NK cells. The serum lysozyme concentration showed a significantly higher value at day 0 and 4 (p<0.05) with whole wheat consumption. It was concluded that immunomodulating polysaccharides from whole wheat as part of the daily diet have no statistical significant influence on the non-specific immune response of man.

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