Regioselective Synthesis of Carbonyl-Containing Alkyl Chlorides via Silver-Catalyzed Ring-Opening Chlorination of Cycloalkanols
2016
Huang, Feng-Qing | Xie, Jian | Sun, Jian'guo | Wang, Yue-Wei | Dong, Xin | Qi, Lian-Wen | Zhang, Bo
A novel and regioselective approach to carbonyl-containing alkyl chlorides via silver-catalyzed ring-opening chlorination of cycloalkanols is reported. Concurrent C(sp³)–C(sp³) bond cleavage and C(sp³)–Cl bond formation efficiently occur with good yields under mild conditions, and the chlorinated products are readily transformed into other useful synthetic intermediates and drugs. The reaction features complete regioselectivity, high efficiency, and excellent practicality.
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