Regioselective Synthesis of Carbonyl-Containing Alkyl Chlorides via Silver-Catalyzed Ring-Opening Chlorination of Cycloalkanols
2016
Huang, Feng-Qing | Xie, Jian | Sun, Jian'guo | Wang, Yue-Wei | Dong, Xin | Qi, Lian-Wen | Zhang, Bo
A novel and regioselective approach to carbonyl-containing alkyl chlorides via silver-catalyzed ring-opening chlorination of cycloalkanols is reported. Concurrent C(sp³)–C(sp³) bond cleavage and C(sp³)–Cl bond formation efficiently occur with good yields under mild conditions, and the chlorinated products are readily transformed into other useful synthetic intermediates and drugs. The reaction features complete regioselectivity, high efficiency, and excellent practicality.
显示更多 [+] 显示较少 [-]AGROVOC关键词
书目信息
Organic letters
卷
18
期
4
页码
684
- 687
ISSN
1523-7052
出版者
American Chemical Society
其它主题
Cleavage (chemistry); Regioselectivity
语言
英语
类型
Journal Article; Text
2024-02-28
MODS