Regioselective ortho-acetoxylation/methoxylation of N-(2-benzoylphenyl)benzamides via substrate directed C–H activation
2011
Reddy, B.V Subba | Revathi, G. | Reddy, A Srinivas | Yadav, J.S.
A highly regioselective ortho-acetoxylation of N-(2-benzoylphenyl)benzamides has been achieved using a catalytic amount of Pd(OAc)₂ (10mol%) and a stoichiometric amount of PhI(OAc)₂ in a mixture of acetic anhydride and acetic acid via C–H activation to produce the corresponding 2-acetoxybenzamides in good yields. ortho-Methoxylation has been accomplished using methanol under similar conditions.
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