Blood pressure and hormone changes associated with weight reduction in the obese
1982
Sowers, James R. | Nyby, Michael | Stern, Naftali | Beck, Frances | Baron, Steven | Catania, Robert | Vlachis, Nicholas
Changes in blood pressure (BP), pulse rate, plasma catecholamines, prolactin (PRL), plasma renin activity (PRA), and aldosterone response to upright posture and isometric handgrip exercise were examined in 20 obese patients (15 females, 5 males; ages 22-55; body weight at least 25% above ideal) during 12 weeks of weight reduction on a hypocaloric diet. Plasma norephinephrine (PNE) correlated with BP prior to weight loss. Reductions in BP after exercise correlated with PNE reductions after exercise. While epinephrine levels in plasma declined with PNE levels, dopamine increased during the 1st 2 weeks on the diet. Prolactin rose significantly prior to weight loss following exercise, but not after dieting. Plasma levels of PRA and aldosterone after exercise declined after 8 weeks of dieting, with PRA reductions correlated with PNE reductions. The results suggest that BP reductions associated with caloric restriction in the obese patients occur from reduced sympathetic nervous system activity and secondary effects of reduced adrenergic activity. (wz)
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