Functionalized C-nucleosides as remarkable RNA binders: targeting of prokaryotic ribosomal A-site RNA
2019
Joly, Jean-Patrick | Gaysinski, Marc | Zara, Lorena | Duca, Maria | Benhida, Rachid
RNA represents an extremely promising and yet challenging therapeutic target. Here, we report the design of a series of C-nucleosides as original RNA binders. Some of them bind strongly and selectively to A-site prokaryotic ribosomal RNA.
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