Ni/Chiral Sodium Carboxylate Dual Catalyzed Asymmetric O-Propargylation
2021
Xu, Xianghong | Peng, Lingzi | Chang, Xihao | Guo, Chang
A highly enantioselective O-propargylation catalyzed by combining a phosphine–nickel complex and an axially chiral sodium dicarboxylate has been developed. The transformation features mild reaction conditions, a broad substrate scope, and excellent functional group tolerance, offering an efficient approach to an array of enantioenriched O-propargyl hydroxylamines. Mechanistic studies support the presumed role of the chiral carboxylate as a counterion for nickel catalysis enabling the discovery of highly stereoselective transformations. The power of this reaction is illustrated by its application in the asymmetric total synthesis of potent firefly luciferase inhibitors and (S)-dihydroyashabushiketol.
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