In vitro anti-HIV-1 properties of ethnobotanically selected South African plants used in the treatment of sexually transmitted diseases
2008
Tshikalange, T.E. | Meyer, J.J.M. | Lall, N. | Muñoz, E. | Sancho, R. | Van de Venter, M. | Oosthuizen, V.
Ethopharmacological relevance: The plants selected in this study are used traditionally in the treatment of sexually transmitted diseases and traditional healers interviewed claimed these plants can also help AIDS patients. Aim: To evaluating the in vitro anti-HIV properties of selected plants in various bioassays. Materials and Methods: The extracts were evaluated for their inhibition against α-glycohydrolase, reverse transcriptase and viral proteins (NF-κB and Tat) which play a significant role in the HIV life cycle. Results: Terminalia sericea extract (IC₅₀ =92mg/ml) exhibited a considerable α-glucosidase inhibitory activity which was better than acarbose (IC₅₀ =131mg/ml) under our assay conditions. In the reverse transcriptase assay, T. sericea also showed good inhibitory activity (IC₅₀ =43mg/ml), which was higher than that of the reference drug, Adriamycin (IC₅₀ =100mg/ml). The ethyl acetate extract of Elaeodendron transvaalense exhibited the most potent inhibitory activity in both the NF-κB and Tat assays with inhibitory activity of 76% and 75% respectively at a concentration of 15mg/ml. The acetone and chloroform extracts of E. transvaalense and Zanthoxylum davyi also showed good activity in the NF-κB and Tat assays.
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