Evaluation of Adverse Effects of Antibiotics on Broiler Chickens
2020
Tarek, Khenenou | Riad, Bouzid | Soumia, Rahem | Ibtessem, Labied | Nadji, Boulebda | Berghiche, Amine
To evaluate the impact of uncontrolled use of veterinary drugs on broilers in eastern Algeria, an experimental plan was developed for the evaluation and identification of drug toxicity in 60 chickens (30 treated and 30 non-treated with antibiotics) using analysis of serum biochemical parameters, autopsy, morpho-metric and histopathological analysis of certain internal organs. The results of the serum biochemical analysis revealed that the uric acid and aspartate aminotransferase values in antibiotic-treated chickens were high, while the lesion status showed a dominance of respiratory lesions, followed by digestive lesions, particularly hepatic lesions. The morphometric study of the internal organs (liver, kidney, and intestine) demonstrated that abnormal liver appearance was very important with minor atrophic changes in the kidney, while the histopathological examination of the liver revealed the presence of deposition in the center of the hexagons in the apical area with an apparent homogeneous structure of fibrous connective tissue. Also, there were apparent deep sinus defects in peripheral areas with an overload of fibrin. The histopathological examination of the kidneys revealed proximal tubular atrophy in the renal parenchyma along with loss of distal intratubular consistency to the peripheral zone of homogeneous structure persuading the peripheral edema. It is concluded that the uncontrolled use of antibiotics in the poultry industry leading to a moderate to severe toxicity.
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