Key determinants of success in fecal microbiota transplantation: From microbiome to clinic
2023
Porcari, Serena | Benech, Nicolas | Valles-Colomer, Mireia | Segata, Nicola | Gasbarrini, Antonio | Cammarota, Giovanni | Sokol, Harry | Ianiro, Gianluca | Università cattolica del Sacro Cuore [Milano] (Unicatt) | Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon | Hospices Civils de Lyon (HCL) | Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL) ; Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) | Centre for Integrative Biology (CIBIO), University of Trento (CIBIO) ; Università degli Studi di Trento = University of Trento (UNITN) | Università degli Studi di Trento = University of Trento (UNITN) | Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt) | MICrobiologie de l'ALImentation au Service de la Santé (MICALIS) ; AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | French Group of Fecal Microbiota Transplantation [Paris] (GFTF) | Centre de Recherche Saint-Antoine (CRSA) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU) | CHU Saint-Antoine [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | ANR-20-CE14-0005,antIDOte,Manipuler les metabolites d'IDO dans les MICI(2020)
International audience
Mostrar más [+] Menos [-]Inglés. Fecal microbiota transplantation (FMT) has achieved satisfactory results in preventing the recurrence of Clostridioides difficile infection, but these positive outcomes have only been partially replicated in other diseases. Several factors influence FMT success, including those related to donors and recipients (including diversity and specific composition of the gut microbiome, immune system, and host genetics) as well as to working protocols (fecal amount and number of infusions, route of delivery, and adjuvant treatments). Moreover, initial evidence suggests that the clinical success of FMT may be related to the degree of donor microbial engraftment. The application of cutting-edge technologies for microbiome assessment, along with changes in the current vision of fecal transplants, are expected to improve FMT protocols and outcomes. Here, we review the key determinants of FMT success and insights and strategies that will enable a close integration of lab-based and clinical approaches for increasing FMT success.
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Este registro bibliográfico ha sido proporcionado por Institut national de la recherche agronomique
