TOXICOPATHOLOGICAL STUDIES OF DI BUTYL PHTHALATE IN MALE WISTAR RATS
2024
Rina R. Patel | B. P. Joshi | D.J. Ghodasara | J. H. Khorajiya | Priya D. Ghodasara | Sunanda Pandey
Di butyl phthalate (DBP) is a most important plasticizer which is suspected as reproductive toxicant and exposure to it has the potential effect on the human as well as animal reproductive system. The research work was conducted to evaluate the repeated dose toxicity of di butyl phthalate in male wistar rats. The animals were divided in four different groups with 12 male rats in each group. Group I served as control and was administered corn oil (2 ml/kg body wt.) while groups II, III, and IV were administered DBP orally at the dose rate of 500, 1000 and 2000 mg/kg respectively for consecutive seven days. Three rats from each group were sacrificed at 24 hrs, 7th day, 14th day and 21st day after initial dosing. There was gradual decrease in WBC count, RBC count, Hb, HCT, MCV, MCH, MCHC, gradual increase in albumin, gradual decrease in total protein, glucose values, gradual decrease in relative weights of the testes, epididymis, prostate and seminal vesicles as well as increase in liver weight with increase in dose of DBP in group II, III and IV as compared to control group at different intervals of sacrifice. Grossly reductions in the size of testes were observed only in rats that belonged to high dose group IV on 21st day. The plasticizer DBP was found to produce histopathological lesions in male reproductive organs as well as in liver in dose dependent manner after oral administration. The finding suggested that DBP can cause toxicity lesions in male reproductive organs especially in testes and epididymis at the dose rate of 500 to 2000 mg/kg body weight in wistar rats.
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