Functional genomics of HMGN3a and SMARCAL1 in early mammalian embryogenesis
2009
Rodríguez Osorio, Nélida | Uzun, Alper | Kaya, Abdullah | Wang, Hongfeng | Parrish, John J. | Ilyin, Valentin A. | Memili, Erdogan | CENTAURO
ABSTRACT: Background: Embryonic genome activation (EGA) is a critical event for the preimplantation embryo, which is manifested by changes in chromatin structure, transcriptional machinery, expression of embryonic genes, and degradation of maternal transcripts. The objectives of this study were to determine transcript abundance of HMGN3a and SMARCAL1 in mature bovine oocytes and early bovine embryos, to perform comparative functional genomics analysis of these genes across mammals.
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