Measurement of the Absolute Value of Cerebral Blood Volume and Optical Properties in Term Neonates Immediately after Birth Using Near-Infrared Time-Resolved Spectroscopy: A Preliminary Observation Study
2019
Aya Morimoto | Shinji Nakamura | Masashiro Sugino | Kosuke Koyano | Yinmon Htun | Makoto Arioka | Noriko Fuke | Ami Mizuo | Takayuki Yokota | Ikuko Kato | Yukihiko Konishi | Sonoko Kondo | Takashi Iwase | Saneyuki Yasuda | Takashi Kusaka
The aim of this study was to use near-infrared time-resolved spectroscopy (TRS) to determine the absolute values of cerebral blood volume (CBV) and cerebral hemoglobin oxygen saturation (ScO<sub>2</sub>) during the immediate transition period in term neonates and the changes in optical properties such as the differential pathlength factor (DPF) and reduced scattering coefficient (μ<sub>s</sub>’). CBV and ScO<sub>2</sub> were measured using TRS during the first 15 min after birth by vaginal delivery in term neonates who did not need resuscitation. Within 2−3 min after birth, CBV showed various changes such as increases or decreases, followed by a gradual decrease until 15 min and then stability (mean (SD) mL/100 g brain: 2 min, 3.09 (0.74); 3 min, 3.01 (0.77); 5 min, 2.69 (0.77); 10 min, 2.40 (0.61), 15 min, 2.08 (0.47)). ScO<sub>2</sub> showed a gradual increase, then kept increasing or became a stable reading. The DPF and μ<sub>s</sub>’ values (mean (SD) at 762, 800, and 836 nm) were stable during the first 15 min after birth (DPF: 4.47 (0.38), 4.41 (0.32), and 4.06 (0.28)/cm; μ<sub>s</sub>’: 6.54 (0.67), 5.82 (0.84), and 5.43 (0.95)/cm). Accordingly, we proved that TRS can stably measure cerebral hemodynamics, despite the dramatic physiological changes occurring at this time in the labor room.
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