NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice
2023
Yoshitaka Murakami | Fan-Yan Wei | Yoshimi Kawamura | Haruki Horiguchi | Tsuyoshi Kadomatsu | Keishi Miyata | Kyoko Miura | Yuichi Oike | Yukio Ando | Mitsuharu Ueda | Kazuhito Tomizawa | Takeshi Chujo
A mitochondrial tRNA modification enzyme, NSUN3, is found to be essential for embryonic development in mice, with whole-body knockout causing embryonic lethality and heart-specific Nsun3 knockout leading to heart aberration in older mice.
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