Nuclear pore complex and stem cell homeostasis
2021
Li Lanzhu | Ji Zhejun | Zhang Weiqi | Qu Jing | Liu Guanghui
As a channel for mediating exchange between the nucleus and cytoplasm, the nuclear pore complex (NPC) is a macromolecular complex composed of about 30 nucleoporins. In addition to mediating nucleocytoplasmic transport, NPC can also regulate chromatin organization and gene expression. The maintenance of stemcell homeostasis plays an essential role in the regeneration and repair of tissues, organs, and body homeostasis.More and more studies have shown that NPC and nucleoporins can regulate stem cell proliferation and differentiation, and affect stem cell homeostasis. This article reviews the related research on NPC and its influence on stemcell homeostasis, hoping to provide new ideas for the regulation and maintenance of stem cell homeostasis.
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