Anti-obese effect of iodine-enriched yolk in cultured adipocytes
2016
Yokoyama, J. (Nosan Corporation, Yokohama, Kanagawa (Japan)) | So, K.H. | Suzuki, Y. | Morioka, M. | Suzuki, K. | Katoh, K. | Roh, S.
This study was to investigate the effect of iodine-enriched yolk extract on fat accumulation in vitro in cultured 3T3-L1 adipocyte for confirming the function as the functional food. The extracts of iodine-enriched and ordinary yolk at the doses of 5, 10, 50 microg/mL were treated after adipocyte differentiation and their effects in intracellular fat accumulation were compared by the analyzing the oil-red staining, GPDH activity and adipogenic-associated genes. Iodine-enriched yolk with dose of 50 microg/mL significantly inhibited the fat accumulation in adipocytes compared with ordinary yolk. In addition, adipogenic-associated genes, i.e. PPAR-gamma2, adipogenin, leptin and adiponectin, was significantly inhibited by treatment of iodine-enriched yolk. However, iodide ion (lsup(-)) treatment did not affect the fat accumulation in cultured adipocytes. These results indicate that the iodine bounded components including iodine peptide, not iodide ion, in iodine-enriched yolk may inhibit the fat accumulation in cultured adipocytes.
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