Grey mullet roe contains yolk protein having IgE cross-reactivity to chum salmon roe major allergen (Onc k 5)
2017
Li, Z. (Hokkaido University, Hakodate, Hokkaido (Japan). Faculty of Fisheries Sciences) | Shimizu, Y. | Saeki, H.
The major allergenic protein in grey mullet roe was immunologically characterized using rabbit IgG against the beta'-component, which is a vitellogenin fragment and the major allergen in chum salmon roe, and the IgE cross-reactivity between salmon and mullet roe was examined using chum salmon roe-allergic patients' sera. Grey mullet beta'-component was identified in the yolk protein and consisted of 16 and 30 kDa proteins that showed marked reaction with the anti-beta'-component IgG and shared N-terminal amino acid sequence similarity with vitellogenin. The grey mullet beta'-component consisted of six different isoforms generated from vitellogenin A and vitellogenin B, and they inhibited the IgE-binding reaction between chum salmon beta'-component and a chum salmon roe-allergic patient's serum. Thus, grey mullet roe may be an allergenic seafood capable of introducing IgE cross-reactivity to chum salmon roe through the beta'-component.
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