Sperm DNA fragmentation test: usefulness in assessing male fertility and assisted reproductive technology outcomes
2023
Evgeni, Evangelini | Sabbaghian, Marjan | Saleh, Ramadan | Gül, Murat | Vogiatzi, Paraskevi | Durairajanayagam, Damayanthi | Jindal, Sunil | Parmegiani, Lodovico | Boitrelle, Florence | Colpi, Giovanni | Agarwal, Ashok | Royan Institute for Reproductive Biomedicine [Tehran, Iran] | Sohag University | Faculty of Medicine [Selcuk University Konya, Turkey] ; Selçuk University = Selçuk Üniversitesi | Universiti Teknologi MARA [Shah Alam] (UiTM) | CHI Poissy-Saint-Germain | Biologie de la Reproduction, Environnement, Epigénétique & Développement (BREED) ; École nationale vétérinaire d'Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Cleveland Clinic
International audience
Mostrar más [+] Menos [-]Inglés. Male infertility is attributed to multiple factors including high levels of sperm DNA fragmentation (SDF). Conventional semen analysis continues to be the gold standard for diagnosis of male factor infertility around the world. However, the limitations of basic semen analysis have prompted the search for complementary assessments of sperm function and integrity. Sperm DNA fragmentation assays (direct or indirect) are emerging as important diagnostic tools in male infertility workups, and have been advocated for use in infertile couples for a variety of reasons. While a controlled degree of DNA nicking is required for appropriate DNA compaction, excessive fragmentation of sperm DNA is linked to impaired male fertility potential, decreased fertilization, poor embryo quality, recurrent pregnancy loss, and failure of assisted reproductive technology procedures. However, there is an ongoing debate regarding whether or not to employ SDF as a routine test for male infertility. This review compiles up-to-date information regarding the pathophysiology of SDF, the currently available SDF tests, and the role of SDF tests in natural and assisted conception conditions.
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