Central regulation of intestinal motility by somatostatin and cholecystokinin octapeptide | Regulation centrale de la motricite intestinale par la somatostatine et par l'octapeptide cholecystokinine
1982
Bueno, Lionel | Ferre, Jean-Pierre | Unité de recherche Pharmacologie-Toxicologie (UPT) ; Institut National de la Recherche Agronomique (INRA) | Physiopathologie et Toxicologie Expérimentales (UPTE) ; Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)
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Mostrar más [+] Menos [-]Inglés. When injected continuously into the lateral ventricles of the rat, somatostatin increased the frequency of the migrating myoelectric complexes of the small intestine in a dose-related manner. A significant increase was obtained at a dose as low as 0.066 picomole per minute. In contrast, cholecystokinin octapeptide decreased the frequency of the migrating myoelectric complex of the small intestine or disrupted this pattern when injected into the lateral ventricle at rates of 0.073 to 0.23 picomole per minute. These findings support the hypothesis that somatostatin and cholecystokinin octapeptide act on central nervous system structures that are involved in the control of intestinal motility.
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