A genomic duplication in Arabidopsis thaliana contains a sequence similar to the human gene coding for SAP130
2001
Casacuberta, Josep M. | Puigdomènech, Pere | Monfort, Amparo | European Commission | Generalitat de Catalunya | Comisión Interministerial de Ciencia y Tecnología, CICYT (España)
The Arabidopsis thaliana gene orthologue to human SAP130 is contained in a perfect genomic duplication of 4.3 kb. The 1 217-aa AtSAP130 protein is 73 % similar to the human gene that is also present in the Caenorhabditis elegans, Drosophila melanogaster and Sacharomyces pombe genomes. The duplicated sequence includes the coding region, two introns, a 32-bp segment in the 5’ non-coding region and 420 bp of 3’ non-coding region that contains an intron. Sequence homology with ESTs suggests that at least one of the gene copies is transcribed. The presence of the 4.5-kb inverted duplicated sequence has been verified in thirteen ecotypes of A. thaliana. Size variation was detected relative to the Columbia ecotype and corresponds to the deletion of a 3’ non-coding region that is flanked by a 110-bp tandem repeat. The AtSAP130 duplication appears to be a recent event in the Arabidopsis species evolution.
Mostrar más [+] Menos [-]The present work has been funded by grants from the European Union (Arabidopsis BIO4-CT98-0549 ‘EU Sequencing on Arabidopsis chromosome 3’) and CICYT (grant BIO98-1838-CE). The work has been carried out within the framework of ‘Centre de Referència de Biotecnologia de la Generalitat de Catalunya’.
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