Rheological and mechanical properties of hydrophilic dispersions using a new hydrophobically modified polymer and Igepal (R) CO520
2011
Lucero Muñoz, María Jesús | Claro Cala, Carmen María | Casas Delgado, Marta | Jiménez Castellanos, María Rosa | Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | Instituto de Biomedicina de Sevilla (IBIS) | Universidad de Sevilla. CTS-1015: Desarrollo galénico de medicamentos y productos cosméticos | Universidad de Sevilla. CTS-547: Caracterización y optimización estadística de medicamentos | Universidad de Sevilla. CTS-1074: Inmunonutrición e inmunometabolismo
Hydroxypropyl cellulose-methyl methacrylate and non-ionic surfactant Igepal (R) CO520 (20-25% (w/w)) have been characterized in aqueous-based dispersions for topical application systems. The systems have similar viscosity curves independent of the surfactant's concentration, showing shear-thinning fluids. Also, the elastic and viscous moduli are constant and independent of critical stress values applied; however, the storage modulus was always higher than the loss modulus. Both parameters showed a slightly dependence on the applied frequency, indicating a gel-like behavior. The complex dynamic viscosity increases until 23% (w/w) of surfactant, keeps then constant. The hardness, compressibility and adhesiveness parameters increase when increase the Igepal (R) CO520 concentration. The adhesiveness properties are 18-47% higher than the compressibility ones, with low values for hardness (similar to 0.4 N). While fracture and Hencky's strain values increase when increase the surfactant concentration, fracture work decreased, and no relation is found to deformability modulus. Also, the dispersed system with 20% (w/w) of Igepal CO520 has less stiffness than with 25% (w/w). (C) 2011 Elsevier Ltd. All rights reserved.
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