Exploring the Antineoplastic Properties of the Lebanese <i>Jania rubens</i> Against Colorectal Cancer
2025
Mariam Rifi | Zeina Radwan | Nouha Sari-Chmayssem | Rayan Kassir | Ziad Fajloun | Abir Abdel Rahman | Marwan El-Sabban | Corinne Prévostel | Zeina Dassouki | Hiba Mawlawi
Background/Objective: Colon cancer poses a significant health burden, with current treatments often associated with severe side effects and limited effectiveness for some patients. Natural products are gaining interest as adjuvant therapies, potentially reducing side effects and improving responses to conventional treatments. We previously highlighted the potent antineoplastic effects of organic extracts derived from the Lebanese red algae <i>Jania rubens</i>. This study, investigated the anticancer activities of polysaccharide, protein, and lipid extracts from <i>J. rubens</i>, which may serve as adjuvant therapies to enhance conventional treatments. Methods: we employed colorimetric assays, wound healing assays, and cell cycle analysis to evaluate the anticancer activities of the extracts. The polysaccharide extract was characterized for sulfate content and structure using barium chloride-gelatin and FT-IR methods. Results: All <i>J. rubens</i> extracts exhibited significant anticancer effects, with the polysaccharide extract showing particularly strong cytotoxicity, apoptosis induction, and antiproliferative and anti-migratory activities. Conclusion: These findings confirm that <i>J. rubens</i> is a source of bioactive compounds with anticancer potential. Further investigations are needed to elucidate the molecular pathways targeted by <i>J. rubens</i> extracts in cancer cells.
Mostrar más [+] Menos [-]Palabras clave de AGROVOC
Información bibliográfica
Este registro bibliográfico ha sido proporcionado por Directory of Open Access Journals