Histological Effects of Potassium Dichromate on Ovaries and Thyroid Gland in Adult Female Rats
2025
Ola Raad Bader, Murtada Faraj Abdul-Hussein.
The current study was designed to Know the Potassium dichromate (chromium) effects of histological structure on ovaries and thyroid glands in adult female rats. Twenty-one adult female rats were divided into three groups. The first group (n=7) animals received distal water as the control group, the second group (n=7) animals received potassium dichromate dissolved in distal water at a dose (n= 8.5 mg\kg), and the third group (n=7) animals received potassium dichromate at a dose (n= 4.25 mg\kg) dissolved in distal water. Animals received chromium orally by gavage for 30 days. The animals were sacrificed at the last experiment and the ovaries and thyroid have been isolated for histological study. Results showed normal ovarian histological structure in the control group and normal collagen fibers surrounding the vascular tissues. The potassium dichromate-treated group showed cysts, hemorrhage, distortion of granulosa cells, and collagen fibers not appearing with high doses. Histological ovarian sections in the treated group at a low dose of chromium showed normal ovarian structure with few fibroblasts. Normal thyroid follicles appeared in the control group. Thyroid gland structure in the treatment group at high doses of chromium showed the epithelium follicles have hyperplasia with distortion of follicle cells and walls. The follicles in the low dose group of chromium showed damage to follicle cells, vacuolated and limited hyperplasia. Therefore, chromium directly or indirectly affects of ovaries and thyroid glands
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