ANTICOAGULANT EFFECTS OF EMINIUM SPICULATUM AQUEOUS LEAF EXTRACT IN RABBITS
2013
M. I. Al-Farwachi and B.A. AL- Badranii
The effect of different doses of Eminium spiculatum aqueous leaf extract on coagulation of blood in the rabbits were studied .Animals treated with extract at a dose of 200 , and 400 mg / kg body weight intraperitoneally daily for 7 days produced a significant ( p < 0.05 ) increase in the clotting time , prothrombin time and activated partial thromboplastin time with normal platelet counts when compared with phosphate buffer saline ( untreated ) and heparin ( treated ) control rabbits. The effect of the extract on coagulation of the blood was shown to be dose – dependent . Result of this study suggest that extract shows considerable anticoagulant activity in rabbits and has potential to reduce cardiovascular morbidity and mortality.
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