A STUDY OF TOXIC EFFECT OF SODIUM BENZOATE, VIT. C ALONE AND THEIR COMBINATION ON REPRODUCTIVE FUNCTIONS OF ADULT MALE RABBITS
2018
Shahid M | Nawras A. Alwan | Eman Aboud Al-Masoudi
The present study was designed to determine the adverse effect of sodium benzoate(SB), vitamin C (Vit.C) alone and of their combination on reproductive functions inrabbits. Thirty-six adult male rabbits were divided randomly into six equal groups. Group1 (Control group) received orally distal water, group 2: Vit.C (200mg/kg BW/day)received orally, group 3: received orally SB (60 mg/kg BW/day), group 4: received orallySB (120 mg/kg BW/day). Group 5: received orally SB+Vit.C (60+200 mg/ kg BW/day)and group 6: received orally SB+Vit.C (120+200 mg/ kg BW/day). The result revealed asignificant decrease in serum testosterone concentrations in all treated groups ascompared with Vit.C and control group. Significant differences were observed in spermconcentration, viability, abnormality and significant decrease in sperm motility in groupstreated with combination of SB and Vit.C as compared with control. A significantimprovement in sperm concentration, sperm motility, viability and abnormality in G2(Vit.C) group compared with all-treated groups. Histopathological changes in testiculartissues in groups treated with SB+Vit.C showed marked vacuolation and degeneration ofseminiferous tubules, with arresting of spermatogenesis.
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