Oxysterol-Induced Inflammation in Human Diseases: Strategies for Treatment with Natural Compounds and Synthetic Molecules
2025
Brahmi, Fatiha | Mackrill, John, J. | Ghzaiel, Imen | Rezig, Leila | Benkhalifa, Rym | Zarrouk, Amira | Jouanny, Pierre | Vejux, Anne | Lizard, Gérard | Université Abderrahmane Mira [Université de Béjaïa] = University of Béjaïa = جامعة بجاية (UB) | University College Cork (UCC) | Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne) ; Université Clermont Auvergne (UCA) | Université de Carthage (Tunisie) = University of Carthage (UCAR) | Tunis El Manar University [University of Tunis El Manar] [Tunisia] = Université de Tunis El Manar [Tunisie] = جامعة تونس المنار (ar) (UTM) | جامعة المنستير - Université de Monastir - University of Monastir (UM) | جامعة سوسة = Université de Sousse = University of Sousse (USO) | CHU Dijon ; Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon) | Université Bourgogne Europe (UBE) | Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA) ; Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Dijon ; Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université Bourgogne Europe (UBE) | France & PHYNOHA Consulting, Fontaine-lès-Dijon | This work was supported by the Université de Bourgogne Europe (Dijon, France), Université de Bejaia (Bejaia, Algeria) and University College of Cork, Irland).
International audience
Mostrar más [+] Menos [-]Inglés. Oxysterols can be derived from the diet, physiologically produced via specific enzymes, or are generated by autoxidation. These molecules have physiological properties and can also adversely affect vital organs. Indeed, some of them have pro-oxidant and pro-inflammatory activities and can lead to major pathologies. The present review focuses on oxysterols (7-ketocholesterol, 7β-hydroxycholesterol, 25-hydroxycholesterol, 27-hydroxycholesterol, 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, and cholestane-3β, 5α, 6β-triol) involved either in cholesterol metabolism, age-related diseases (such as cardiovascular, neurodegenerative, and eye diseases, e.g., sarcopenia), and inflammatory diseases (especially Behcet’s disease and bowel and lung diseases (e.g., sarcoidosis, COVID-19)). Metabolic pathways associated with oxysterol-induced inflammation are discussed considering the cytokinic TLR4 pathway, non-cytokinic pathways, and the contribution of Ca2+ and K+ channels. Therapeutic approaches targeting oxysterol-induced inflammation either by natural or synthetic molecules are also presented.
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