Antioxidative Activity and Lipophilicity Determination of Steroidal Semi- and Thiosemicarbazones
2024
Živković, M. B. | Tufegdžić, S. J. | Novaković, I. T. | Šegan, S. B. | Sladić, D. M.
Anti-DPPH activity and in silico lipophilicity of six steroidal semi- and thiosemicarbazones were determined. As expected, sulfur derivatives exhibited higher activity than oxygen analogues. Lipophilicity determined by the shake flask method (logP=4.5±0.2) for androstane thiosemicarbazone with the best antioxidative activity of 0.298 mM was in good agreement with the value obtained by calculation using the Chemaxon calculator (logP=4.62).
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Información bibliográfica
Editorial Vinča Institute of Nuclear Sciences – National Institute of the Republic of Serbia, University of Belgrade
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