Background: Oxidative stress and inflammation are strictly connected, and both perform an important role in the pathogenesis of diabetes mellitus (DM).Objectives: This research aimed to investigate the potential protective effect of kudzu root against oxidative stress and inflammation in a streptozotocin (STZ)-induced DM animal model.Methods: DM was induced in male Wistar rats by intraperitoneal injection of STZ (50 mg/kg body weight). The kudzu root (100 mg/kg BW) was administered orally after 1 week of STZ administration in diabetic animals (for 6 weeks).Results: The diabetic animals exhibited a significant increase in fasting blood glucose, tumor necrosis factor-alpha, and malondialdehyde levels. However, they exhibited a significant decrease in plasma insulin level, superoxide dismutase, and glutathione peroxidase activity. Administration of kudzu root to diabetic animals reversed these effects.Conclusion: The current study indicated that kudzu root has potent antidiabetic properties, likely through its anti-inflammatory and anti-oxidative properties in the STZ-diabetic rat model.

BACKGROUND: Diabetes mellitus is one of the most common metabolic disorders with a severe impact on the quality of life. OBJECTIVES: The objective of the present study was to investigate the impact of the hydroalcoholic extract of Eryngos on blood glucose, blood cells, and pancreatic tissue. METHODS: Thirty-five male rats were prepared. After diabetes induction by streptozotocin, they were randomly divided into 5 groups, including; non-diabetic control, diabetic control, diabetic treated with hydroalcoholic extract of Eryngos at doses of 300 and 500 mg/kg administered intraperitoneally, and metformin at a dose of 500 mg/kg. At the end of the study, glucose level was measured, and blood cells and pancreatic tissue were examined. RESULTS: Hydroalcoholic extract of Eryngos caused a significant reduction in blood glucose. Given the adverse effects of diabetes on the number of WBC, Eryngos extract at a dose of 300 mg/kg had a protective effect on the number of WBC. It decreased their number significantly compared with the diabetic control group. This effect was the same for both diabetic and non-diabetic groups. Histopathological results also indicated that Eryngos extract significantly increased the number of islets of Langerhans and beta cells. CONCLUSIONS: The results suggest that the hydroalcoholic extract of Eryngos may be effective in the treatment of diabetes. Moreover, based on the biochemical and histological results, it can be concluded that the hypoglycemic effect of the extract is probably due to the restoration and repair of the islets of Langerhans

Background: Diabetes is a metabolic disease that is associated with hyperglycemia and infertility. Previous studies indicate that aloe vera may positively affect the blood glucose and fertility. Objective: the present study was carried out to evaluate effect of aloe vera on serum oxidant/antioxidant activity and reproductive hormones following experimental diabetes. Methods: sixty adults male wistar rats were divided to 5 groups. control group(A) was kept without treatment. Group(E) only received aloe vera gel(400 mg/kg-orally). Experimental diabete mellitus was induced in 3 groups of rats by streptozotocin( 65 mg/kg-Ip). One diabetic group was kept without treatment(B). Another diabetic group received aloe vera gel(400 mg/kg-orally)(C) and another received insulin(10 units)(D). Aloe vera gel and insulin was administration for 30 days then, the rats were anesthetized and blood collected. The amount of malondialdehid(MDA), anti oxidant activity(AOA), glutathion peroxidase activity(GPX), thiol protein(TSH), testosterone, LH and FSH was determined in serum. Results: level of testosterone was significantly decreased while amount of MDA, TSH, GPX and AOA was significantly increased in non-treated diabetic rats. Aloe vera increased antioxidant defense. Conclusions: Aloe vera improves antioxidant activity and reduces diabetic complications. Key words: Diabetes, Aloe vera, Anti oxidant, pituitary – sexual hormones, rat.