This study was conducted to investigate the effects of organic, NPK, and biofertilizers on the yield of two cowpea varieties grown under arid land conditions. Two cultivars of cowpea (Karim-7 and Dokki-331) were evaluated using different fertilizer types. The fertilizers examined were organic (farmyard manure (FYM) and chicken manure (CHM)) and biofertilizers (effective microorganisms (EM1) and technology of smart fertilizer (TS)) in addition to NPK treatments (NPK (50 kg/fed), NPK (100 kg/fed), EM1 (15 m3.fed-1) + NPK (50 kg/fed), TS (15 m3.fed-1) + NPK (50 kg/fed). A randomized complete block design (RCBD) with 16 treatments and three replications was used to set up the experiment. The measured yield parameters were seed number/plant, pod length, seed number/pod, pod number/plant, dry yield/plant, dry yield/m2, bio yield, pod weight, 100-seed weight, and grain yield. The results cleared that the cultivar dokki-331 under EM1 biofertilizer + NPK (50 kg/fed) combination treatment was the superior practice for increasing all studied traits.