Mated female moth of the cotton leafworm, S. littoralis laid a total number of 1564.22 eggs during its whole life. In a free choice test, treating N. oleander leaves (as an oviposition site) with an aqueous extracts of neem seed kernel solutions extracted by different organic solvents reduced the number of deposited eggs on it. The lowest number of eggs was recorded when methanol was used for extraction, followed by chloroform, and the highest was, however, obtained after using benzene, butanol and ethyl acetate. The number of deposited eggs decreased as the concentration of any tested neem extract increased to reach the minimum at 0.2%. This means that the most deterred neem seed kernel extract is that which extracted with methanol at the concentration of 0.2%.Hatchability percentage of S. littoralis eggs greatly affected by the type of organic solvents used for neem extraction and the concentration of each extract on treated N. oleander leaves. The lowest hatchability was recorded after using methanol, followed by chloroform.On the other hand, an increase in neem seed kernel extract concentration caused an obvious decrease in egg hatchability.