Stimulation of bovine alveolar macrophages with calcium ionophore A23187 resulted in marked production of leukotriene (LT)B4 and a lesser increase in thromboxane (TX)B2, whereas opsonized zymosan (OPZ) resulted in production of TXB2 and relatively small increases in LTB4 and prostaglandin (PG)F2 alpha. Alveolar macrophages incubated with recombinant bovine interferon-gamma or lipopolysaccharide, and subsequently stimulated with A23187 or OPZ, had altered arachidonic acid metabolism, producing markedly increased amounts of TXB2 and PGF2 alpha, and slightly increased LTB4. Incubation of alveolar macrophages with lipopolysaccharide had a more profound effect on the increased amounts of TXB2 and PGF2 alpha, observed in response to stimulation with A23187 or OPZ, than did incubation with interferon-gamma. Alveolar macrophages incubated with recombinant bovine interferon-alpha 1-1 also produced slightly increased amounts of LTB4 when stimulated with A23187 or OPZ. Altered arachidonic acid metabolism by alveolar macrophages exposed to interferons and lipopolysaccharide may contribute to the development of pulmonary inflammation, such as in the early stages of bacterial pneumonia following viral infections that induce interferon production.

Evaluation of amino-acid, mineral, and vitamin content, as well as indexes of meat safety obtained from young stock of cattle of different genotypes in accordance with possibility of its application as raw material for baby food production was realized in the conditions of the Republic of Belarus. In course of study there were used bull calves of white-and-black breed, Limousin breed and their crossbreeds. Research results showed that young stock of Limousin breed, Limousin x white-and-black crossbreds, and white-and-black breed (control group) gave high quality meat. In meat of animals of experimental groups there was stated high quality of almost all nonessential amino acids and nonreplaceable amino acids, in meat of crossbreeds there was noted considerable increasing of polyunsaturated fatty acids. In it there was 12,31% of linoleic acid against 4,75 in Limousin breed and 2,77% in white-and-black breed; and eicosatetraenoic acid – 2,4% against 1,24% and 0,7%, respectively. Also in meat of experimental bull calves there was stated higher content of vitamins, calcium and phosphorus, while the content of cuprum and zinc decreased