The study was done on sixty bird divided equally into four groups, firstgroup untreated control, second group low dose, third group intermediatedose and forth group high dose. The toxic effect of aflatoxin B2 in pigeonresult in histopathological changes in digestive tract mainly interstatial edemain muscular layer of muscularis externa with prominent (thicken) muscularisexterna, large blood vessels in the serosa with congestion perivascularfibrosis and prominent adipose tissue and elongation of villi of smallintestine, vacuolation of ilet of Langerhans of pancreas. In theproventricullus, prominent lamina properia and focal congestion and dilatedmucus gland of lamina properia. proventricullus with dilated mucous gland.In the respiratory system in lung areas of inflammatory cells in alveoli. Innervous system in brain with vacuolation in white matter.