In this study, prevalence of clinical diseases and disorders of goat at upazilla veterinary hospital, Pirojpur, Bangladesh were calculated and analyzed based on age, sex and seasonal variation during the period from June, 2014 to May, 2015. The protocol of disease diagnosis was mainly based on clinical sings, physical examination and some common laboratory techniques. Total 277 clinical cases (diseases and disorders) of goat were recorded for this study.The prevalence of medicinal, surgical and gynecological cases were 47.29%, 41.16% and 11.55%; respectively. In medicinal cases, prevalence of diarrhea was highest (22.90%) compare to bloat (13.74%), pestedes-petites ruminant (13.74%), shipping fever (12.98%), fever (11.45%), conjunctivitis (11.45%), mite infestation (10.69%) and tetanus (3.05%). Female (63.36%) and older goat (54.20%) were more susceptible to different types of medicinal cases. In surgical cases, prevalence of castration was highest (52.63%) compare to abscess (17.54%), dog bite (16.67%) and foot rot (13.16%). Summer season represented highest surgical case (49.12%) prevalence followed by winter season (33.33%) and rainy season (17.54%). In gynecological cases, prevalence of retained placenta was highest (37.50%) compare to vaginal prolapsed (31.25%) and dystocia (31.25%). Seasonal variation was also observed in gynecological cases and summer season (50%) represented highest case prevalence followed by winter season (37.5%) and rainy season (12.50%).Those prevalence of different diseases and disorders of goat will helpful for clinician to know the disease occurrence according to goat’s age, sex and seasonal variation in this area and will help them to take proper preventive measures against those diseases and disorders.