Realization of veterinary and sanitary examination of meat and slaughter products of calves treated with hyperimmune serum against cattle colibacillosis was conducted in the conditions of the Republic of Belarus. There were formed two groups calves of 3-5 days old. Calves of the first group were treated with serum biological preparation of trial series produced at Vitebsk Biofabrika (Belarus). Calves of the second group were intact animals. Calves of each group were killed in 14 days after preparation application for realization of veterinary-sanitary examination. Slaughter meat was studied in accordance with the following indexes: pH; peroxidase activity; presence of products of primary protein breakdown; moisture content; relative biological value of meat; bacterial examination. The research results of organoleptic indicators showed that meat of both groups corresponded to the standards. Hyperimmune serum against colibacillosis of live-stock animals did not render negative influence on organoleptic, physical and chemical indexes of meat. Indexes of the relative biological value in meat of calves treated with the examined serum were higher than the similar indexes of intact animals. Meat of all examined animals did not have any germs of toxico-infections and toxicoses

Evaluation of pathogenicity of Paenibacillus alvei culture obtained from a dead bee brood from Berezinsky Biosphere Nature Reserve was realized in the conditions of the Republic of Belarus by an example of 30-day old white male mice with body weight of 16-18 grams. Experimental animals were infected with European foul brood (Paenibacillus alvei) intraperitoneally. Research results showed that bacteria Paenibacillus alvei after the intraperitoneal infection with various amount of microbial cells did not cause mouse death; i.e. it was not pathogenic for white mice. In course of the realized observations over the laboratory mice after introduction of infection there were stated no changes in mice behavior and overall condition. There were no visible pathologicoanatomic changes in internal organs. After the bacteriologic examination of internal organs and blood there were isolated pure cultures of Paenibacillus alvei

Creation of effective and easy-to-replicate in laboratory conditions culture medium for isolation of salmonella out of water, which could make it possible to increase the safety, authenticity and efficiency of bacteriological study of aquatic medium objects, was realized in the conditions of the Republic of Belarus. In course of the numorous preliminary experiments there was developed an enrichment medium containing the following: nutrient yeast (5 g/l); potassium phosphate monosubstituted (8,6 g/l); sodium hydrate (1,4 g/l); 0,1% brilliant green solution (5 cm3/l); 0,01% solution of crystal violet (10 cm3/l); distilled water (1 l). The analyzed medium was estimated in accordance with the following propertiesd: medium sensitivity; efficiency; inhibition of bacteria growing. Research result showed that the experimental medium was more sensitive in comparison with the selenite one. Studying of the efficiency of the compared media showed that accumulation of test strains of S. enteritidis on the experimental medium was in 10E4 times higher, S. typhi – in 10E3; S. typhiniurium, S. anatum was in 10 times higher than at selenite media. The experimental studies proved that the experimental culture medium for salmonella isolation out of city water and surface water was more sensitive and easier to use than the selenite medium

Serological properties of leptospirae bacteria grown on differential nutritive media were studied by the example of sheep in the conditions of the Republic of Belarus. In the experiment there were used 6 pathogenic industrial leptospirae stock: Leptospira pomona VGNKI-6; Leptospira tarassovi VGNKI-4; Leptospira grippothyphosa VGNKI-1; Leptospira icterrohaemorragia VGNKI-2; Leptospira conicola VGNKI-3; Leptospira hardjo VGNKI-5. The results showed a serological difference of leptospirae grown on conventional and experimental media derived from ram's blood.

Investigation of antimicrobial activity of liquid extractions from the following medicinal plants and their mixtures against S. aureus, B. subtilis, E. coli, P. aeruginosa, and P. vulgaris was realized in the conditions of the Republic of Belarus: peat moss (Sphagnum); greater plantain (Plantago major); plumepoppy (Macleaya); common comfrey (Symphytum officinale); speckled alder (Alnus incana). Research results showed that the best results for septic wounds treatment were obtained apter application of mixture of plumepoppy and greater plantain as it showed the acute antimicrobial, anti-inflammatory, and wound-healthing effect. Antimicrobial activity of the analyzed infusion formula revealed in quicker (on 3-6 days in comparison with control) wound cleansing from microorganisms, quick lowering of bacterial content up to 10E3 bodies per 1 g of tissue and in provision of wound healing without inclusion of saprogenous microflora. Anti-inflammatory effect was characterized by quick (by 2 days) cancellation of acute inflammatory response, that was revealed in lowering of neutrophilic leukocytes quantity up to 59,8 +/- 0,49 %; quicker normalization hematologic indexes and early reduction of perifocal edema; weakening of hyperthemia and hyperemia; decreasing of wound secretion without purulence; absence of leaks and leak pouch; normalization of microcirculation in wound. Wound-healthing effect was revealed in increasing of fibroblast number from 7,1 +/- 0,4 % up to 29,4 +/- 0,4 % on the 7th day and in activation proliferate and synthetically function