Refinar búsqueda
Resultados 1-8 de 8
Expression of CD133, CD44, CK7, and OCT4 in Animal Cancers
2013
Park, J.H., Chungnam National University, Daejeon, Republic of Korea | Cho, E.S., Chungnam National University, Daejeon, Republic of Korea | Ryu, S.Y., Chungnam National University, Daejeon, Republic of Korea | Jung, J.Y., Chungnam National University, Daejeon, Republic of Korea | Son, H.Y., Chungnam National University, Daejeon, Republic of Korea
Cancers are mainly sustained by a small pool of neoplastic cells, known as cancer stem cells or tumorinitiating cells. These cells possess the ability to self-renew and proliferate, and are thus able to form the tumor. In the present study cells that correspond to cancer stem cells in mammary and liver cancers in animals were identified by the expression of CD133, CD44, CK7, and OCT4 using immunochemistry. As a result, we found with CD133+ and CD44+ cancer stem cell-like phenotypes in mouse and canine hepatocellular carcinoma and canine mammary gland tumors. However, CK7+ and OCT4+ cells were not identified in animal mammary and liver cancer. CD133+ and CD44+ cells are wellknown stem cell lines and play key roles in development and metastasis in human cancer. These findings suggest that cancer stem cells are involved in animal tumorigenesis and may provide insight into mechanisms in cancer development as well as cancer diagnostics.
Mostrar más [+] Menos [-]Therapeutic effects of 1alpha,25 dihydroxycholecalciferol on osteoporotic fracture in a rat model
1999
Bae, C.S. (Konkuk University, Seoul (Korea republic). Department of Surgery, Faculty of Veterinary Medicine)
Osteoporosis is defined as a decrease in bone mass that leads to an increased risk of fracture. The therapeutic effect of 1alpha,25 dihydroxycholecalciferol, the hormonal form of vitamin D3 that mediates calcium translation in intestine and bone, on the healing process of fracture has still been controversial. These studies were designed to understand the healing process of normal fibular fracture, the osteoporotic changes after ovariectomy, and the theraqeutic effects of 1alpha,25 dihydroxycholecalciferol on the osteoporotic fracture in rats. The simple transverse fractures of rat fibulae were produced with a rotating diamond saw. The changes of the biochemical and mechanical indices of rats were investigated. The mechanical study based on bending test revealed the healing of the fibular fracture in the 5th week after simple transverse fracture. The osteoporosis impaired more the healing of osteoporotic fibular fracture than normal non-osteoporotic fibular fracture. The healing process of osteoporotic fracture was facilitated by the treatment with 1alpha,25 dihydroxycholecalciferol, however was delayed more than the healing process of normal fracture. The bone strength based on the bending test also confirmed this tendency. The bone strengths in the 5th week after fracture of normal bone, osteoporotic bone, and 1alpha,25 dihydroxycholecalciferol-treated osteoporotic bone were 75%, 41% and 67%, respectively, in comparison with those of intact bone. In conclusion, 1alpha,25 dihydroxycholecalciferol was effective in promoting the osteroporotic fracture healing.
Mostrar más [+] Menos [-]The effects of electroacupuncture and laser at Da-zhui and Shen-shu on hematologic changes and blood concentration of endocrine substances in dogs
1999
Cho, Y.S. | Bae, C.S. (Konkuk University, Seoul (Korea republic). Faculty of Veterinary Medicine)
This study was carried out (a) to investigate the variations of blood chemistry and (b) to examine the secretion trend of endocrine substances in a dog model after electroacupuncture and laser stimulation at different time period(9 to 11a.m. and 6 to 8p.m.). Two acupuncture points; Da Zhui(GV-14) and Shen Shu(BL-23) were electroacupunctured for 20 minutes with 2Vol, 20Hz and irradiated for 5 minutes with 8,000Hz. Before stimulation and after a lapse of time(10-minutes, 30-minutes and 60-minutes) all dogs were checked the following parameters; cortisol, ACTH, RBC, hemoglobin, hematocrit, WBC, Ca, P, SGPT, SGOT and creatinine. The results were as follow:The levels of cortisol and ACTH have been increased 10 minutes after the stimulation of the electroacupuncture and laser. The higher levels of cortisol and ACTH have been decreased to keep the normal levels from 30 minutes after the stimulation of the electroacupuncture and laser. The RBC, hemoglobin, hematocrit and WBC showed the physiological phenomena in the electroacupuncture and laser stimulation. In sero chemical analysis, calcium, phosphate, SGOT, SGPT and creatinine levels were within normal physiological ranges.
Mostrar más [+] Menos [-]Comparison of enzyme cytochemical activities between rosetted cells in peripheral blood of Korean native cattle
1997
Kim, N.S. | Seo, Y.W. (Chung Bu Branch of the Kang Won-Do Veterinary Service Laboratory, Wonju (Korea Republic)) | Song, H.J. (Chonbuk National University, Chonju (Korea Republic). College of Veterinary Medicine) | Kim, S.J. (Kon-Kuk University, Seoul (Korea Republic). Department of Veterinary Medicine)
Effect of Euonymus alatus and Ulmus clavidiana var japonica on the immune system
1994
Kim, J.M. | Cho, J.G. | Jung, Y.M. | Park, T.W. (Chonbuk National University, Chonju (Korea Republic). College of Veterinary Medicine) | Choi, M.S. (Kunsan National University, Kunsan (Korea Republic). College of Ocean Science and Technology)
Effects of colostrum-conferred passive immunity on disease incidence in Korean native calves during the suckling period
1989
Kim, D. | Han, H.R. (Seoul National Univ., Suwon (Korea R.). Coll. of Veterinary Medicine)
The effects of the serum total protein and immunoglobulin levels of the colostrum-conferred Korean native calves at 2 days of age on the disease incidence during the suckling period were studied. Serum total protein, total immunoglobulin, IgG, and IgM levels of 6 Korean native calves died from septicemia were lower than those of calves survived (p0.05). Korean native calves having low serum total protein and immunoglobulins were affected with diarrhea earlier in life, when compared with calves having high serum levels (P0.05). Korea native calves having low serum total protein were affected with bronchopneumonia earlier in life, when compared with calves having high serum levels (P0.05). Korean native calves having low serum neutralizing antibody titers to bovine viral diarrhea virus had high incidence rate of BVD, when compared with calves having having high serum neutralizing antibody titers (P0.05)
Mostrar más [+] Menos [-]Enhancement of cell-mediated immunity by administration of plasma protein in pigs-(1)-Proportion of leukocyte subpopulations and cells expressing adhesion molecules in peripheral blood
1994
Yang, C.K. (Thaihan Industry Company, Seoul (Korea Republic). Veterinary Diagnostic Laboratory) | Kim, S.J. (Konkuk University, Seoul (Korea Republic). Department of Veterinary Medicine) | Moon, J.S. | Jung, S.C. | Park, Y.H. (Rural Development Administration, Anyang (Korea Republic). Veterinary Research Institute)
Enhancement of cell-mediated immunity by administration of plasma protein in pigs-(2)-Proportion of T lymphocyte subpopulations and cells expressing MHC class 1, 2 molecules in peripheral blood
1994
Yang, C.K. (Thaihan Industry Company, Seoul (Korea Republic). Veterinary Diagnostic Laboratory) | Kim, S.J. (Konkuk University, Seoul (Korea Republic). Department of Veterinary Medicine) | Moon, J.S. | Jung, S.C. | Park, Y.H. (Rural Development Administration, Anyang (Korea Republic). Veterinary Research Institute)