Investigation of method of gastroenteritis treatment of stores by means of application of enterosorbents was realized in the conditions of the Republic of Belarus. For the experiment there was used preparation Lactofiltrum containing 80% of hydrolyzed lignin and 20% of lactulose applied in dose of 0,3 g/kg once a day during 7 days. Efficiency of application of Lactofiltrum was compared with enterosorbent SV-2, which contained alcaline hydrolyzed lignin applied in dose of 1 g/kg once a day during 7 days. Four experimental groups piglets sick with gastroenteritis in the age of 1,5-2 months, with body weight of 15-17 kg were used in the experiment. The first group piglets were entered 0,3 g/kg body mass of Lactofiltrum once a day during 7 days. The second group piglets were entered enterosorbent SV-2 in dose of 1 g/kg in course of 7 days. For the piglets of the third group there was applied the complex of analysed preparations in same course of treatment. The fourth group of piglets was entered enrotim 10% in dose of 1 ml/ 20 kg of body mass. All animals had the same conditions of feeding and keeping. Research results showed that application of Lactofiltrum, SV-2 and their complex provided high antioxidative, detoxification, gepathoprotective activities. These preparations proved to be effective means of pathogenetic therapy for the treatment of gastroenteritis of piglets, both as individual preparations, and complex application. Comparative estimation of treatment methods of gastroenteritis showed that these preparations (except enrotim 10%) made it possible to regulate the metabolic processes due to elimination of intoxication, positive influence on hematopoiesis. The preparations lowered the duration of clinic manifestation of a disease and facilitated its duration, had gepathoprotective and antioxidative activity