In the conditions of the Republic of Belarus there were determined the parameters of acute and subacute toxicological characteristics of the developed in the Vitebsk State Academy of Veterinary Medicine anthelmintic preparations of durable action Febolvetum-О for control of sheep strongylatosis and Febolvetum for control of strongylatosis of cattle young stock. Data on determination of toxicological parameters of the prolonged action bolus were presented. Research results showed that the preparations did not render negative influence on laboratory animals (white mice). According to the parameters of acute oral toxicity the Febolvetum was qualify as the third hazard class. In accordance with the results of study of subacute toxicity parameters of the preparations, it was concluded, that in the conditions of free feeding of Febolvetum boluse in combination with forages in course of 30 days in doses of 200 mg/kg; 150 mg/kg; 100 mg/kg of body weight in animals there were found no signs of intoxication; there were not stated any is not fixed deviations in physiological state; and were stated no mice death.

In the conditions of the Republic of Belarus there was studied the application of sodium chloride obtained by electrolysis method on Akvamed installation in a complex of activities for the preventive measures of animal helminthoses. Electrochemical activation of aqueous solution of sodium chloride proved to be a progressive and rational technology which made it possible to substantially reduce the material costs and power consumption for the development of highly efficient and ecologically safe disinvasion solution. Application of sodium chloride solution with the minimal content of available chlorine of 3,0 g/l provided the death of 94-95% of Taeniidae eggs in course of 30 minutes after applicated of the preparation on the treated surface. The proposed method can be recommended as the most efficient and economically effective for the disinvasion of external environment.

In the conditions of the Republic of Belarus there was analyzed fauna of parasites of gastro-intestinal tract and natural resistance of horses in the conditions of Polesye State Radiation Ecological Reserve. There were worked the most efficient antihelminthic compounds. Analysis of helminthological state showed that extensiveness helminthic and gastrophilosis invasion of horses was at a high level. In this regard the nematodosis and gastrophilosis (Gastrophilus intestinalis) invasions prevailed. In mature and growing horses there was marked the dominance of nematode worms of Strongylidae / Trichonematidae families (78,9-83,8%) and Gasterophilidae (95,8%). Next, at growing horses there were stated nematodes Strongyloides westeri and cestoid worms of Anoplocephalidae family, at mature horses – of Gasterophilidae, Parascaris equorum and Oxyuris equi families. The following antihelminthic compounds ans preparations showed the best efficiency: Univerm; Avermektin paste 1%; Fenbendazoli, Rivertin 1%.

In course of realized in the conditions of the Republic of Belarus research there were studied the relations of the most widely spread helminthes and protozoan which infest in gastrointestinal tract of dogs with the normal microflora of small intestine and large intestine. Research results showed that in the conditions of single-agent infestation and associative parasitic disease of dogs caused by Toxocara canis, Toxascaris leonine, Dipylidium caninum, Uncinaria stenocephala, Taenia sp., Isospora ochioensis, Isospora canis and Eimeria canis in small and large intestine of sick animals there was seldom stated the changes of quality and quantity composition of microflora. In the conditions of mixed agents infestation the microflora composition changed more intensively

There was estimated the indogenic intoxication development in animal, experimentally affected with larval cestodoses and its influence on meat quality. In the tabular form the indicators of farm animal parasitizing with larval cestodoses are presented; development indicators of endogenic intoxications of sheep parasitized with cysticercus; development indicators of endogenic intoxications of the rats parasitized with echinococcus larvacyst; dynamics of hematological indicators at sheep, experimentally infected with eggs Т Hydatigena; dynamics of hematological indicators of the laboratory rats experimentally infected with eggs Е granulosus; organoleptic meat characteristics of healthy sheep and sheep which affected with С Tenuicollis; biological value of sheep meat. As a result of the spent research it is revealed, that parasitizing of larval cestodoses at farm animals is accompanied by development of endogenic intoxications and as consequence considerably reduces quality of meat production. | Цель работы заключалась в оценке развития эндогенной интоксикации у животных, экспериментально инвазированных яйцами тениид, и ее влияния на качество получаемой мясной продукции. В табличной форме представлены показатели пораженности сельскохозяйственных животных личиночными формами цестод; показатели развития эндогенной интоксикации овец, пораженных цистицерками тенуикольными; показатели развития эндогенной интоксикации крыс, пораженных ларвоцистами эхинококка; динамика гематологических показателей у овец, экспериментально инвазированных яйцами Т. Hydatigena; динамика гематологических показателей лабораторных крыс, экспериментально зараженных яйцами Е. granulosus; органолептические показатели мяса овец здоровых и пораженных С. Tenuicollis; биологическая ценность мяса овец. В результате проведенных исследований выявлено, что паразитирование личиночных форм цестод у сельскохозяйственных животных сопровождается развитием эндогенной интоксикации и как следствие значительно снижает качество мясной продукции.

Research on determination of changes of morphological and biochemical blood indexes of sheep with fasciolosis after application of the drug Klozantsid (menizol 20%, produced in the Republic of Belarus) was carried out. The research realized in the conditions of the Scientific and Research Institute of Applied Veterinary Medicine and Biotechnology of the Vitebsk State Academy of Veterinary Medicine. In course of the experiment there were used sheep of Romanovskaya breed at the age from 1,5 till 5 years which were spontaneously infected with fasciola. The experimental animals were administrated with the examined antihelminthic preparation. It was found out that after administration of the preparation there was stated the restoration of a level of erythrocytes, haemoglobin, leukocytes, enzymes, proteins and other blood indexes. Klozantsid did not render toxic influence on studied animals. | Проведены исследования по выяснению изменений морфологических и биохимических показателей крови у овец с фасциолёзной инвазией при применении препарата Клозанцид. Исследования проводили в условиях клиники и лаборатории кафедры паразитологии и инвазионных болезней, лаборатории кафедры клинической диагностики, научно-исследовательского института прикладной ветеринарной медицины и биотехнологии учреждения образования «Витебская ордена «Знак Почёта» государственная академия ветеринарной медицины». Объектом исследования являлись овцы романовской породы в возрасте от 1,5 до 5 лет, спонтанно зараженные фасциолами, которым применяли испытуемый препарат, обладающий антигельминтными свойствами. При этом выяснено, что после введения препарата происходит восстановление уровня эритроцитов, гемоглобина, лейкоцитов, ферментов, белков и других показателей. Клозанцид не оказывал токсического влияния на организм животного.

Despite of presence of a wide choice of antihelminthics, in the Republic of Belarus it is still a real problem of development of preparations that provide long-term treatment and preventive maintenance efficiency against helminthosis. At the same time, helminthes and anthelminthics render the immunosuppression action. The solution of this problem can be a combined application of antihelminthics and adjuvants. There were proposed preparations Albepolis and Averpolis. Their application made it possible not only to release an organism of animals from parasites, but also to correct the state of immune system. The obtained research data confirm the available data about the immunosuppression action of parasites on an organism of animals. There was also is noted the immunosuppression action of Albendazol and Aversektin C in therapeutic doses. Albendazol possess a wide spectrum of action against trematodes, nematodes, cestodes. It interrupts the metabolism, oppresses fumarate reductase activity and adenosine triphosphate synthesis of a parasite. It proved to be low-toxic for homoiothermal animals. Albendazol rendered positove influence on growth, development and increase of cattle productivity.

Development of scientifically based activities for rehabilitation of waterfowl (ducks) against helminthoses on the territory of the Republic of Belarus was realized. In course of the study there were analyzed fauna of helminthes and revelation of the main ways of their circulation in environment conditions; expansion and species composition of mollusks of Belarusian Poozerye; determination of species composition of metacercaria revealed in mollusks. In course of determination of intermediate and additional hosts of helminth infestation of ducks it was noted that the main carriers of larval stages of helminthes in ducks were the following species of frash-water mollusks: Vivaparus contectus; Vivaparus vivaparus; Galba palustris; Radix ovata; Radix auricularia; Sphaerium subsolidum; Bithynia tentaculata; Planorbis carinatus; Planorbis planorbis; Coretus corneus. In the studied samples there were revealed metacercaria of Echinostoma revolutum; Hypoderaeum conoideum; Cataropis verrucosa; Echinostoma dietsi. Assumption that some representatives of molluscum (Viviparus contectus; Viviparus viviparus; Planorbis planorbis) were the transport hosts for echinostomiasis was not proved.

Data оn evaluations of therapeutic efficacy of albendazol and fenbendazol agaonst acute and chronic forms of larval cestodiasis of animals were studied in the conditions of the Republic of Belarus by an example of experimentally infested sheep and rabbits. Application of albendazol and fenbendazol both separately and in complex with antioxidant vitamin and mineral additive against the chronic forms of cysticercosis tenuicollis and cysticercosis pisiform was inefficient. But application of albendazol against acute form of cysticercoses caused the lowering of invasion intensity in shepp and rabbits in 3 times, fenbendazol – in 2,6 times. Application of anthelmintic agents in complex with vitamin and mineral composition promoted the lowering of invasion intensity (in 5 and 4,1 times, respectively) and prevented the disease development in 60% of animals.

In the conditions of the Republic of Belarus there was studied the pathology and biology of cattle capillariasis. Capillariosis invasion rendered a substantial invasion on blood morphological composition which was revealed in lowering of erythrocytes and hematoglobulin, as well as in increasing of leukocytes quantity. There was noted the lowering of the natural resistance and immune reactivity. There were stated substantial deviations in protein metabolism which was expressed in lowering of total protein, quantity of albumins, changing of albumin and globulin coefficient, increasing of globulins. In the conditions of blood biochemical analysis of infesrated animals there was stated a disorder of vitamin and mineral metabolism; increasing of alanine aminotransferase and aspartate aminotransferase enzymes activity. Development of Capillaria bovis was realized in a direct line. In the natural habitat development of Capillaria bovis eggs varied from two up to three months.