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Pyrrolizidine alkaloid-induced liver disease in horses: an early diagnosis.
1988
Mendel V.E. | Witt M.R. | Gitchell B.S. | Gribble D.N. | Rogers Q.R. | Segall H.J. | Knight H.D.
Antipyrine and caffeine dispositions in clinically normal dogs and dogs with progressive liver disease.
1994
Boothe D.M. | Cullen J.M. | Calvin J.A. | Jenkins W.L. | Brown S.A. | Green R.A. | Corrier D.E.
Dispositions of caffeine and antipyrine were compared as indicators of decreasing hepatic function in dogs with experimentally induced progressive liver disease. Dimethylnitrosamine, a hepatospecific toxin, was administered orally to 16 dogs; 6 dogs served as controls (group 1). Three classes of liver disease were defined by histologic features: mild (group 2; n = 5), moderate (group 3; n = 6), and severe (group 4; n = 5). Disposition of antipyrine, and 24 hours later, caffeine was studied 3 weeks after the last dose of toxin in each dog. For both drugs, rapid IV administration of 20 mg/kg of body weight was administered and serum samples were obtained at intervals for determination of at least 5 terminal-phase drug half-lives. For both drugs, clearance and mean residence time differed among groups (P less than or equal to 0.01). Clearance of antipyrine and caffeine was decreased in groups 3 and 4, compared with groups 1 and 2. Antipyrine and caffeine mean residence times were longer in group-3 dogs, compared with dogs of groups 1 and 2. Correction of caffeine and antipyrine clearances for hepatic weight increased discrimination between groups 3 and 4. The clearance and mean residence time ratios of antipyrine to caffeine were calculated for each group and, when compared with values for group-1 dogs, were used to test for differences between the 2 drugs in response to disease. Ratios did not differ among groups. These results indicate that the disposition of antipyrine and caffeine may change similarly with progression of dimethylnitrosamine-induced liver disease.
Mostrar más [+] Menos [-]Indocyanine green disposition in healthy dogs and dogs with mild, moderate, or severe dimethylnitrosamine-induced hepatic disease.
1992
Boothe D.M. | Brown S.A. | Jenkins W.L. | Green R.A. | Cullen J.M. | Corrier D.E.
Disposition kinetics of indocyanine green (ICG) were used to evaluate hepatic function in healthy Beagles (group 1; n = 6) and Beagles with progressive hepatic disease induced by oral administration of dimethylnitrosamine, a hepatospecific toxin. Three classes of hepatic disease were defined by histologic features: mild (group 2; n = 5), moderate (group 3; n = 6), and severe (group 4; n = 5). Disposition of ICG was studied 3 weeks following the last dose of toxin. A rapid IV injection of 0.5 mg of ICG/kg was administered and serum samples were obtained at certain intervals during 60-minute periods. Serum ICG was analyzed by use of visible spectrophotometry. Disposition kinetics were determined from serum ICG concentrations vs 15- and 60-minute time curves and compared between one another and among groups. Data based on 60-minute time curves were not significantly different from those based on 15-minute curves. Area under the curve for ICG was greatest in group 3. Clearance of ICG was decreased and mean resident time was increased in groups 3 and 4, compared with those in groups 1 and 2. When disposition data (60 minutes) were normalized for differences in hepatic weight among dogs, group-3 mean resident time was significantly greater than that of group 4. This study supports the diagnostic benefits of using ICG disposition kinetics as a method of evaluating hepatic function in dogs with progressive liver disease.
Mostrar más [+] Menos [-]Oxidative stress and bovine liver diseases: Role of glutathione peroxidase and glucose 6-phosphate dehydrogenase
2007
Ellah, M.R.A.(Iwate Univ., Morioka (Japan). Faculty of Agriculture) | Okada, K. | Yasuda, J.
This article summarizes the different types of free radicals, antioxidants and the effect of oxidative stress on the activities of glutathione peroxidase and glucose 6-phosphate dehydrogenase in bovine liver diseases. A growing body of evidence suggests that the formation of reactive oxygen species is a common occurrence associated with most if not all disease processes. The overall importance of reactive oxygen species to the progression and severity of various disease states varies greatly depending on the conditions and whether the disease is acute or chronic. Free radical researches in animals are in progress and further investigations are needed to establish the involvement of reactive oxygen species in diseases affecting different animal species and the pathology they produce.
Mostrar más [+] Menos [-]Pathological studies on the hepatic fibrosis induced by Capillaria hepatica
1998
Shin, E.K. | Han, J.H. (Kangwon National University, Chunchon (Korea Republic). Department of Veterinary Medicine)
An occurrence of duck virus hepatitis in Korea
1985
Park, N.Y. (Chonnam National Univ., Kwangju (Korea R.). Dept. of Veterinary Medicine)
An outbreak of duck virus hepatitis was confirmed for the first time in Korea from ducklings having up to 40-65% mortality in less than 15-day-old ducklings of two farms located in the vicinity of Kwangju city. The infected ducks showed sudden death and opisthotonus position. The predominant gross lesions were found in the liver, showing enlargement and petechial or ecchymotic hemorrhages. The microscopic findings consisted of fatty changes and necrosis of the hepatic cells, and proliferation of the bile duct epithelium
Mostrar más [+] Menos [-]Морфологическое проявление патологий печени у свиней
2009
Lemesh, V.M. | Bondar, T.V. | Pakhomov, P.I., Vitebsk State Academy of Veterinary Medicine (Belarus)
Investigation of frequency of occurrence and manifestations of liver pathology of swine during the postmortem examination at meat packing plant of the Republic of Belarus was realized. Data analysis of reports of postmortem veterinary-sanitary examination gathered from two leasing national meat packing plants showed that out of 236187 of evaluated swine carcasses and organs in 40860 (17,3%) of cases there were registered different liver pathologies. Among the total number of liver pathologies in 5721 cases (14%) there were stated liver pathologies caused by invasive diseases (echinococcus disease (Echinococcus granulosus) – 1,5%; cysticercosis – 0,2%; migration traces of ascarid larva - 12,3%), and 31830 cases (86%) were caused by noncontagious diseases. The highest percentage among noncontagious liver diseases was stated for dystrophic organ changes (83,6%); the other 17,2% were caused by fibroid induration. During the morphological liver analysis there were stated the dystrophic and necrotic changes in fractions with the profound disturbance of blood circulation. At the same there was noted the disturbance of the whole fraction stricture, acute capillary engorgement in the central and peripheral zones
Mostrar más [+] Menos [-]Определение эффективности доз Цинковета при экспериментальной дистрофии белых мышей
2009
Kovalehnok, Yu.K. | Golub, A.A. | Kotovich, I.V. | Lyakh, A.P., Vitebsk State Academy of Veterinary Medicine (Belarus)
In the conditions of the Republic of Belarus there was realized clinical, biochemical, pathological-anatomical and histologic analysis of the efficiency of the national Tsinkovet (Zincovet) preparation doses in cases of experimental liver dystrophy caused by tetrachloromethane of white mice. For the modeling of toxic hepato-dystrophy there was applied tetrachloride carbon. Five tested and 2 controlled groups of scrub white mice were prepared. There were 23-29 mice in each group. Weight of mouse was 18 – 20 g. Conditions of feeding and keeping were the same in each group. 181 mice were used in the test. 5 ml/ kg of carbon tetrachloride was entered subdermal to tested group and the first controlled group mice once a day two days along. Tested dozes were estimated based on preparation toxicity. Maximum doze was 3 mg in 0,5 ml of distilled water for one mouse (1-st group - 3 mg, 2-nd group - 2, 75 mg, 4-th group - 2, 25 mg and 5-th group - 2 mg). Mice mortality was noticed during the experiment. Results of influence of different doses of the studied preparation on liver specific weight and variations of body mass were presented. Activity of amplifiers (succinate dehydrogenase (SDH), glutamate dehydrogenase (GLDH), aspartate aminotransferase (GOT), alanine-aminotransferase (GPT) in blood serum of mice after administration of tetrachloromethane and Tsinkovet preparation was analyzed. Drawings of liver acinus of hepatic steatosis were given. Research results proved that the analyzed zinc containing preparation substantially lowered the toxic action of tetrachloromethane and promoted the regeneration of liver cells
Mostrar más [+] Menos [-]Биохимические методы в гепатологии крупного рогатого скота
2009
Kholod, V.M. | Soboleva, Yu.G., Vitebsk State Academy of Veterinary Medicine (Belarus)
In the conditions of the Republic of Belarus there was made a hepatospecific metabolic profile of cattle blood serum for complex appraisal of liver functional condition. Age-specific peculiarities of biochemical indices including the composition of hepatospecific metabolic profile of cattle blood serum were revealed. On the basis of obtained results there were calculated the appropriate correction coefficients which must be taken into consideration in objective interpretation of laboratory research.
Mostrar más [+] Menos [-]Болезни печени крупного рогатого скота на откорме
2008
Golub, A.A., Vitebsk State Academy of Veterinary Medicine (Belarus)
The purpose of the research was establishment of hepatic diseases spread in cattle fattening. Trials were conducted with total number of hybrids IV-V generation of black-motley heifer with pedigree Hereford bulls. It has been established the wide spread (22,4%) of hepatic pathology. The leading place among all hepatic pathologies belongs to fatty hepatosis (13,4%) with weakly expressed symptoms, decrease of serum protein level, albumin, glucose and increase of bilirubin, globulins, hepatic enzymes and strong pathology-anatomical and histological manifestations. In the tabular form results of histologic research of liver, some biochemical indicators of blood of healthy and sick animals (M +/- m), the clinical symptoms revealed during the various periods are resulted | Целью исследований являлось изучение структуры и установление широты распространения болезней печени у крупного рогатого скота на откорме. Опыты проведены на широком поголовье помесей IV-V поколения тёлок чёрно-пёстрой породы с племенными быками герефордской породы. Установлено широкое (22,4%) распространение гепатопатий. Ведущее место среди различных форм поражения печени принадлежит жировому гепатозу - 13,4%, морфофункцинальный профиль которого определяется слабо выраженными клиническими симптомами, уменьшением уровня общего белка, альбуминов, глюкозы, повышением концентрации билирубина, активности гепатоспецифических ферментов, а также всех фракций глобулинов, яркой и характерной патологоанатомической и гистологической картиной. В табличной форме приведены результаты гистологического исследования печени, некоторые биохимические показатели крови здоровых и больных животных (M +/- m), клинические симптомы, выявленные в различные периоды
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