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A comparative study on the osteoporotic animal models in ddY mouse: ovariectomized and neurectomized models
Lee, H.S.;Hong, P.O.(Daegu Haany University, Gyeongsan, Republic of Korea)E-mail:endohist@dhu.ac.kr | Ku, S.K.(Dong-Wha Pharm. Ind. Co., Anyang, Republic of Korea) | Lee, J.H.(Kyungpook National University, Daegu, Republic of Korea) | Ham, T.S.(Yeungnam University, Gyeongsan, Republic of Korea)
In order to compare the induced time of osteoporosis between ovariectomized and neurectomized models in ddY mice. Experimental groups were divided into Sham, ovariectomized (OVX group) and neurectomized (NX group) group. The changes of body weight, tibia weight and histomorphometry of epiphyseal regions of tibia that were generally used as criteria index in osteoporsis, were evaluated at 2 and 4 weeks after operations with other generally used index-changes of serum osteocalcin. Also, calcium and phosphorus levels in the ash tibia were demonstrated with their ratio (Ca/P ratio).
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