The spectrum of acaricides changes continuously and improves. At the same time, big attention is given to research of new, more effective preparations meeting modern requirements. Research on studying the efficiency of Akaribil preparation against swine sarcoptosis (Sarcoptidae) was realized in the conditions of swine breeding farm in the Republic of Belarus. The preparation possesses high insect-acaricidal activity. In the conditions of the preparation storage and repeated opening of a ware in the course of tests there were stated no changes in drug smell or color. The scheme of the preparation application is applied in industrial production technology. It possesses anti-inflammatory properties, antiseptic stimulating healing of skin damages, does not irritate integuments, renders weak irritating effect on mucous membranes of eyes. In recommended doses Akaribil does not cause any adverse effects and complicating disease. There were stated no contraindications to preparation application. High therapeutic efficiency against arachnoentomosis was proved. Application the preparation made it possible not only to reduce disease incidence and animal death, but also to facilitate the severity of scabietic diseases. As a result of realized research it was established that efficiency of Akaribil against swine sarcoptosis was 100%.

In the conditions of the Republic of Belarus there were determined the parameters of acute and subacute toxicological characteristics of the developed in the Vitebsk State Academy of Veterinary Medicine anthelmintic preparations of durable action Febolvetum-О for control of sheep strongylatosis and Febolvetum for control of strongylatosis of cattle young stock. Data on determination of toxicological parameters of the prolonged action bolus were presented. Research results showed that the preparations did not render negative influence on laboratory animals (white mice). According to the parameters of acute oral toxicity the Febolvetum was qualify as the third hazard class. In accordance with the results of study of subacute toxicity parameters of the preparations, it was concluded, that in the conditions of free feeding of Febolvetum boluse in combination with forages in course of 30 days in doses of 200 mg/kg; 150 mg/kg; 100 mg/kg of body weight in animals there were found no signs of intoxication; there were not stated any is not fixed deviations in physiological state; and were stated no mice death.

In the conditions of the Republic of Belarus there was studied the application of sodium chloride obtained by electrolysis method on Akvamed installation in a complex of activities for the preventive measures of animal helminthoses. Electrochemical activation of aqueous solution of sodium chloride proved to be a progressive and rational technology which made it possible to substantially reduce the material costs and power consumption for the development of highly efficient and ecologically safe disinvasion solution. Application of sodium chloride solution with the minimal content of available chlorine of 3,0 g/l provided the death of 94-95% of Taeniidae eggs in course of 30 minutes after applicated of the preparation on the treated surface. The proposed method can be recommended as the most efficient and economically effective for the disinvasion of external environment.

In the conditions of the Republic of Belarus there was analyzed fauna of parasites of gastro-intestinal tract and natural resistance of horses in the conditions of Polesye State Radiation Ecological Reserve. There were worked the most efficient antihelminthic compounds. Analysis of helminthological state showed that extensiveness helminthic and gastrophilosis invasion of horses was at a high level. In this regard the nematodosis and gastrophilosis (Gastrophilus intestinalis) invasions prevailed. In mature and growing horses there was marked the dominance of nematode worms of Strongylidae / Trichonematidae families (78,9-83,8%) and Gasterophilidae (95,8%). Next, at growing horses there were stated nematodes Strongyloides westeri and cestoid worms of Anoplocephalidae family, at mature horses – of Gasterophilidae, Parascaris equorum and Oxyuris equi families. The following antihelminthic compounds ans preparations showed the best efficiency: Univerm; Avermektin paste 1%; Fenbendazoli, Rivertin 1%.

On the basis of realized in the conditions of the Republic of Belarus research it was established, that Cryptosporidial infection was found at adult and young pigs. The data on influence studying cryptosporidiosis invasion on pathomorphological changes in internal organs of piglets in the conditions of an associative course with infectious. Associative diseases give clearer clinical findings and proceed much harder, with heavier morphological changes. The majority of diseases in the conditions of an associative course proceeds harder in comparison with a mono-infection or invasion. In the conditions of mono-invasion the basic changes are localized in small intestines, causing acute and subacute catarrhal enteritis and a serous inflammation of regional mesenteric lymphonodus. These histological processes are presented as non-uniform locus of infection of a mucous membrane of intestines with atrophy of villus, hypertrophy of crypth and mononuclear polymorphic-nuclear infiltration of basal membranes. In the conditions of association of Cryptosporidial infection with infectious diseases it was noted that the pathomorphological changes progress and are showed not only by catarrhal, but also by hemorrhagic and local necrotic enteritis. Epithelium of mucous membrane is exposed to desquamation, intestines walls become thinner because of meteorism. Thick intestines are also involved into inflammatory process. Associations of Cryptosporidial infection with infectious diseases lead to development of severe pathomorphological changes in intestines. Alteration has prevailing character that is expressed in progressive development of atrophic, dystrophic processes and decline of cells and tissues that conducts to increase of permeability of vessels and proliferation of cells of reticuloendothelial system. | На основании проведенных исследований установлено, что криптоспоридиозная инвазия выявляется у поросят. Представлены данные по изучению влияния инвазии криптоспоридиоза на патоморфологические изменения во внутренних органах поросят при ассоциативном течении с инфекционными болезнями. Ассоциативные заболевания дают более яркую клиническую картину и протекают гораздо тяжелее, с более выраженными морфологическими изменениями в организме. Большинство болезней при ассоциативном течении протекает более тяжело в сравнении с моноинфекцией или инвазией. При моноинвазии основные изменения локализуются в тонком кишечнике, вызывая острый и подострый катаральный энтериты и серозное воспаление регионарных брыжеечных лимфоузлов. Гистологические данные процессы представлены, как неоднородные участки инфицирования слизистой оболочки кишечника с атрофией ворсинок, гипертрофией крипт и мононуклеарной полиморфнооядерной инфильтрацией базальной мембраны. При ассоциации криптоспоридиоза с инфекционными заболеваниями патоморфологические изменения прогрессируют и проявляются не только катаральным, но геморрагическим и очаговым некротическим энтеритами. Эпителий слизистой оболочки подвергается десквамации, стенки кишечника истончаются вследствие метеоризма. В воспалительный процесс также вовлекается толстый кишечник. Ассоциации криптоспоридиоза с инфекционными заболеваниями приводят к развитию в кишечнике тяжелых патоморфологических изменений. Альтерация имеет преобладающих характер, что выражается в прогрессивном развитии атрофических, дистрофических процессов и некроза клеток и тканей, что ведет к повышению проницаемости сосудов и пролиферации клеток ретикулоэндотелиальной системы.

Despite of presence of a wide choice of antihelminthics, in the Republic of Belarus it is still a real problem of development of preparations that provide long-term treatment and preventive maintenance efficiency against helminthosis. At the same time, helminthes and anthelminthics render the immunosuppression action. The solution of this problem can be a combined application of antihelminthics and adjuvants. There were proposed preparations Albepolis and Averpolis. Their application made it possible not only to release an organism of animals from parasites, but also to correct the state of immune system. The obtained research data confirm the available data about the immunosuppression action of parasites on an organism of animals. There was also is noted the immunosuppression action of Albendazol and Aversektin C in therapeutic doses. Albendazol possess a wide spectrum of action against trematodes, nematodes, cestodes. It interrupts the metabolism, oppresses fumarate reductase activity and adenosine triphosphate synthesis of a parasite. It proved to be low-toxic for homoiothermal animals. Albendazol rendered positove influence on growth, development and increase of cattle productivity.

In the conditions of the Republic of Belarus there was determined the parasitizing influence of Oesophagostomum and their larvae on a metabolism of experimentally infested animals. In course of the study there were generated experimental and control groups of two-month old piglets. Animals of the experimental group were infested in a dose of 15000 invasion larvae per one kg of body weight. Animals of the control group were not infested. Infestation was realized through a mouth with invasion larvae with wet forage. Invasion larvae received by cultivation of excrement tests from infested pigs at temperature of 24 deg C. As a result of the realized research it was established, that Oesophagostomum invasion rendered a substantial influence on the experimental animals. At bimestrious pigs after the experimental infection with Oesophagostomum larvae there were stated the following changes: the disease on 4-30th day was characterized by frustration of function of a gastroenteric path - diarrhea, fever, anaemia, and in the subsequent - stagnation and juvenilism of animals. Oesophagostomum in a host organism caused the pathological changes of haemotological and biochemical blood value which were expressed in quantity decrease of erythrocytes, concentration of haemoglobin, leucocytosis. Eosinophilia was observed in a leukogram. In blood serum there was stated the lowering of crude protein and its fractions content; gradually, but authentically there was noted the increasing of activity serum glutamic oxalacetic transaminase and glutamic-pyruvic transaminase. Bactericidal and lysozymic activity of blood serum decreased. Activity of alkaline phosphatase increased.

In the conditions of the Republic of Belarus there was studied the influence of herbal infusion, tincture, liquid and dry extracts of elecampane (Inula helenium) on morphological and biochemical indexes of pig blood. In course of the study it was established, that preparative forms of elecampane stimulated the formation of blood corpuscle, and also increased of the hemoglobin level in blood of pigs. Administration of elecampane preparations did not cause any authentic changes in blood leukogram of swine; all indicators were within normal limits. Elecampane preparations did not cause changes on the part of biochemical blood indexes of and did not influence the activity of enzymes. Research results showed that herbal infusion, tincture, liquid and dry extracts of elecampane did not render negative influence on swine.

In the conditions of the Republic of Belarus there was studied the antihelmintic characteristics of the preparative forms of marsh cinquefoil (Comarum palustre): herbal infusion, infusion, liquid, extract, pulvis. The research has shown that these preparative forms in the specified dozes had a rather high therapeutic efficiency against strongylatosis of gastro-intestinal tract of young ruminants. The highest therapeutic effect was rendered by a liquid extract of Comarum palustre after its administration to animals in a dose of 0,2 ml/kg twice with 24 hour interval. In this case during the strongylatoses of a gastroenteric tract the antiparasitic intensefficiency of sheep and cattle by the end of experience was 98,1% and 97,3% respectively, and antiparasitic extensefficiency was 90% for both kinds of animals. After herbal infusion application of Comarum palustre for animals (in a dose of 7 ml/kg of live weight before feeding once a day within 3 days continuously) by the end of the 14 day of the experiment made it possible to obtain intensefficiency of 70% for both animal species, and extensefficiency of 60% for sheep and 70% - at calves. Tincture application of marsh cinquefoil for animals in a dose of 1 ml/kg of live weight of twice with 24 hours interval, provided the intensefficiency of 85% for sheep and 84% - for cattle, and extensefficiency of 70% and 80%, respectively. In the conditions of application of a pulvis of marsh cinquefoil in a dose of 500 mg/kg of live weight twice with 24 hours interval, made it possible to obtain the 63,4% intensefficiency for sheep and 67,8% - for calves, and extensive efficiency - 50% and 40%, respectively.

In the conditions of the Republic of Belarus there was studied the propagation of associative parasitic diseases of swine of different age-specific groups, as well as their influence on composition of microbial flora of large intestinal tract. As a result of realized studies in different age-sex groups of pigs there were revealed some monoinfections (A. suum; T. suis; Eimeria sp.) and associations (A. sum; T. suis; Eimeria sp.; Oesophagostomum dendatum; B. coli) in different ratio (depending on sex and age-specific groups). There were revealed a certain peculiar features in changing of microbiocenosis of large intestinal tract of swine under the influence of parasitic agents (namely, in cases of parasitic diseases caused by A. suum; T. suis; Eimeria sp.; O. dendatum; B. coli both in the form of mono infestations and in associations). These features were expressed by lowering of standard flora quantity (bifid bacterium and lactic acid bacillus) with a simultaneous increasing of the content of opportunistic coliform bacillus, aerobic bacteria, bacilli, and micromycetes.