Babesiosisis a tick borne hemoprotozoan disease of canines and anaemia is the predominant clinical syndrome. This disease causes considerable morbidity and mortality in canines. Several factors such as leukocyte activation, vascular endothelial cell injury and release of chemical mediators lead to multi-organ failure and coagulation abnormality in complicated form of babesiosis. The assessment of these biomarkers is used as indicators of severity of disease and outcome in dogs with MODS in babesiosis. Successful treatment of babesiosis is challenging task and no drugs have been demonstrated to clear B. gibsoni (Asian genotype) infection. Newer successful treatment has shown encouraging response in cure of B. gibsoni infection which includes combination of clindamycin, metronidazole and doxycycline.